Beatlie currently provides specialist education for pupils aged 3 to 18 with severe and complex medical needs from their campus in Craigshill.
The proposed new purpose-built facility will be a centre of excellence for children and young people, providing cutting-edge educational facilities alongside partner health and wrap around support for children and families.
The new school is being developed as part of phase one of the Scottish Government's new School Investment Programme.
Executive councillor for education David Dodds said: "I'm delighted that we are moving forward to replace the current Beatlie building with a state-of-the-art facility.
"Detailed plans will be developed to deliver the new cutting-edge facility, which is appropriate for the delivery of high-quality services to our young people with severe and complex medical needs.
"We will engage with the school and local community over the detailed proposals for the new Beatlie School.
"West Lothian already has one of the best school estates in Scotland and this new addition will help ensure our young people have the best possible platform for learning."
The new Beatlie School will provide specialist education for up to 44 pupils, eight nursery, 18 primary and 18 secondary places.
Along with the core education facilities, plans for the new school also include a hydrotherapy pool, two general purpose rooms, a life skills area, multi-purpose hall and sensory garden.
Plans for the new school will include the most up-to-date assistive technology products which are designed to help facilitate greater independence for wheelchair users to explore their surroundings by increasing, maintaining or improving their functional capabilities.
In addition to the education facilities, the new school will provide parent support facilities, including accommodation for partner agencies and support services including the NHS Child Development Clinic, which currently support Beatlie School.